Organogels in Drug Delivery: A Special Emphasis on Pluronic Lecithin Organogels

Organogels in drug delivery.

In the last decade, interest in physical organogels has grown rapidly with the discovery and synthesis of a very large number of diverse molecules, which can gel organic solvents at low concentrations. The gelator molecules immobilise large volumes of liquid following their self-assembly into a variety of aggregates such as rods, tubules, fibres and platelets. The many interesting properties of...

The use of Pluronic lecithin organogels in the transdermal delivery of drugs.

This article provides a brief and basic discussion of Pluronic lecithin organogel to include its history, its components, its mechanism of action, the range of active pharmacological agents that can and cannot be incorporated into a Pluronic lecithin organogel, as well as important information for those pharmacists who compound Pluronic lecithin organogel.

An Emerging Era in Topical Delivery: Organogels

Semisolid preparations for external application to skin have gained much demand, since it is easily absorbed through the skin layers. Many novel topical dosage forms have been discovered, among which organogels appears to play an important role. Organogels are thermodynamically stable, biocompatible, isotropic gel, which not only give localised effect, but also systemic effect through percutane...

Topical Delivery of Flurbiprofen from Pluronic Lecithin Organogel

The purpose of this research is to formulate and evaluate the suitability of pluronic lecithin organogels containing flurbiprofen for topical application. Four formulations were developed using flurbiprofen, lecithin, Pluronic F127, isopropyl palmitate, water, sorbic acid and potassium sorbate were coded as FL1, FL2, FL3 and FL4. All the formulations carried 30% w/w of lecithin phase and 70% w/...

Drug Delivery Approaches with Special Emphasis on Chemical Drug Delivery